Nevro Corp. - EN - Providers - Mechanism of Action

All the Frequencies You Need to Deliver Relief

Only Nevro delivers 2 – 10,000 Hz stimulation, enabling multiple mechanisms of action. Senza® systems offer both direct neural inhibition with HF10® therapy and dorsal column stimulation with lower frequencies. These mechanisms can be used simultaneously or independently to help manage chronic pain.

How HF10 Therapy Works

Rather than stimulating the dorsal column, HF10 therapy directly targets inhibitory neurons in the dorsal horn, providing pain relief without paresthesia.1,2

Frequency Matters

Frequencies above 5,000 Hz have a unique inhibitory effect on pain circuitry in the dorsal horn. The stimulation drives inhibitory neurons without meaningfully activating the excitatory neurons. This selective activation, called “direct neural inhibition”, reduces the hyperactivity of wide dynamic range neurons implicated in chronic pain.

Frequency Matters
Frequency is Positively Correlated with Pain Relief

Frequency is Positively Correlated with Pain Relief

In the first frequency titration study in humans, patients were given a range of frequencies to compare clinical outcomes. Only 5,882 Hz demonstrated improved pain relief versus sham. Additional studies on HF10 validate the importance of frequency.

waveforms

Maximum Versatility with Both Mechanisms of Action

Only Nevro systems offer physicians the ability to treat patients with direct neural inhibition and dorsal column stimulation. Waveforms can be paired or delivered independently so you can provide your patients the broadest range of solutions.

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88% of Patients Prefer HF10 therapy5

1. Lee, Kwan et al. High Frequency kHz Spinal Cord Stimulation (SCS) Differently Affects Rodent Superficial Dorsal Horn Cell Types. Poster presented at NANS 2018. 2. McMahon, S. Effects of 10-kHz Spinal Cord Stimulation of the Excitability of Superficial Dorsal Horn Neurons in Experimental Pain Models in the Rat. Poster shown at INS 2017 in Edinburgh. 3. Al-Kaisy, A, et al. Preliminary results from a randomized, sham-control, double blind, cross-over trial of sub-threshold spinal cord stimulation at various kilohertz frequencies (SCS Frequency Study). Poster presented at Neurovations 2016. 4. Kapural L, et al. Comparison of 10-kHz High-Frequency and Traditional Low-Frequency Spinal Cord Stimulation for the Treatment of Chronic Back and Leg Pain: 24-month Results from a Multicenter, Randomized, Controlled Pivotal Trian. Neurosurgery. 2016 5. Tiede J, Brown L, Gekht G, Vallejo R, Yearwood T, Morgan D. Novel spinal cord stimulation parameters in patients with predominant back pain. Neuromodulation. 2013.